Fig. 4
From: Network propagation-based prioritization of long tail genes in 17 cancer types
Comparisons with other methods. a UMGs demonstrate a considerably stronger (CRISPR- and RNAi-measured) impact on survival of cancer cell lines than other non-driver genes suggested by HHotNet (in 3 settings), FDRNet, Zhou et al. (in its original and edge-normalized settings), nCOP, and MutSig. Higher negative values indicate a greater negative effect on cell survival after gene knockdown. b UMGs’ strong impact on the survival of cancer cell lines is significantly broader than that of genes selected by other methods. The median percentage-based score of cancer cell lines negatively impacted by UMGs’ knockout is consistently higher with cancer type specificity