Fig. 8
Chromatin marks at gene transcription start sites and gene bodies correlate with up- and downregulated transcripts following KrasG12D induction. a (i–iv) Average profile plots of normalized H3K27Ac, H3K4Me3, H3K36Me3, and H3K4me1 reads around the transcription start site (TSS) and gene body for upregulated genes at 24 hrs in the RNA-seq data (446 genes). Orange and green shaded areas represent the standard error of the mean. a (v–viii) Red heatmaps show normalized reads around the TSS or gene body for each upregulated gene. b (i–iv) Average profile plots of normalized H3K27Ac, H3K4Me3, H3K36Me3, and H3K4me1 reads around gene TSS and the gene body for downregulated genes at 24 hrs in the RNA-seq data (1165 genes). Color scheme is same as a (i–iv). b (v–viii) Red heatmaps show normalized reads around the TSS or gene body for each downregulated gene