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Fig. 5 | Genome Biology

Fig. 5

From: KrasG12D induces changes in chromatin territories that differentially impact early nuclear reprogramming in pancreatic cells

Fig. 5

Identification of super-enhancers following KrasG12D induction. a, b Super-enhancers identified at a 0 hr and b 24 hrs. c Venn diagram of super-enhancers annotated with genes comparing unique and shared super-enhancers at 0 and 24 hrs. d Pathway enrichment analysis of annotated super-enhancers for 0 and 24 hrs using the MSigDB hallmark gene set collection. Color scale −log10 (FDR). e Gene expression heatmap of all genes associated with super-enhancers at (i) only 0 hr (87 genes) and (ii) only 24 hrs (184 genes). f Gene expression heatmap of the transcription factors associated with super-enhancers at (i) only 0 hr and (ii) only 24 hrs. RPKM values were normalized to the Z scale. g Pathway enrichment analysis of transcription factors for 0 and 24 hrs using MSigDB hallmark gene set collection. Color scale −log10 (FDR)

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