Fig. 5

Validation of bona fide circRNAs in four mammalian species. A Strategy utilized to identify bona fide (true) circRNAs from several tissues from four different mammal species. B The percent of circRNAs identified as “true” positives as a function of the cutoff for circRNAs identified by 1, 2, 3, or 4 of the pipelines used in the indicated species and tissue. C Table summarizing the percentage of common circRNAs selected as true at the chosen threshold. D Table summarizing the number of pipelines that identify the sets of true and false circRNAs identified from the indicated tissues and species. For building this table, we utilized the thresholds marked in (B) as a dotted line and indicated in the table in (C). E Boxplots showing the distribution of expression of the true and false circRNA that are identified in the indicated species