Fig. 5

Decommission of SEs in early stages follows a similar pattern as in SE activation. a Heatmap showing the three types of SEs defined by progressing landscape during differentiation. b Average dynamic profiles of the three types of SEs during differentiation. Each SE is normalized to its maximum H3K27ac intensity during differentiation and the average profile is shown. c Line plot showing the relative expression profiles for genes associated with each type of SEs. Each gene is normalized to its maximum value during differentiation and the average profile is shown. d, e Violin plots showing the fold changes (day 15/day 00) (d) and specificity (e) of genes expression associated with the three types of SEs. f GO analysis showing the enriched functions for the three types of SEs. g Comparison of gene density near the three types of SEs. *P < 0.05, **P < 0.01, ***P < 0.001. P-values are determined by using the Mann-Whitney U test