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Fig. 4 | Genome Biology

Fig. 4

From: Mapping the evolving landscape of super-enhancers during cell differentiation

Fig. 4

Mapping the evolving landscapes of SEs in mouse erythroid cells reveals similar patterns. a K-means clustering of the SE signal vectors across erythroblast differentiation. LTHSC, long-term hematopoietic stem cells; STHSC, short-term hematopoietic stem cells; MPP, multipotent progenitor cells; CMP, common myeloid progenitor; MEP, megakaryocyte erythroid progenitor; EryA and EryB, erythroblasts. b Average dynamic profiles of the three types of SEs during differentiation. Each SE is normalized to its maximum H3K27ac intensity during differentiation and the average profile is shown. c Line plot showing the relative expression profiles for genes associated with each type of SEs. Each gene is normalized to its maximum value during differentiation and the average profile is shown. d, e Comparison of the gene expression fold changes (d) and specificity (e) during differentiation for the three type of SEs. *,P < 0.05, **,P < 0.01, ***,P < 0.001. P-values are determined by using the Mann-Whitney U test. f GO enrichment pattern of the three types of SEs. g Comparison of gene density near the three types of SEs. *P < 0.05, **P < 0.01, ***P < 0.001. P-values are determined by using the Mann-Whitney U test

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