Fig. 2

Characterizations of the three types of SEs. a GO enrichment pattern of the three types of SEs. Top 5 GO terms for each type of SEs are shown after removing redundant terms. b Heatmap showing the overlap between the three types of SEs identified in human cardiomyocytes with SEs in the other 24 tissue types. Numbers in the heatmap stand for the percentage of SEs overlapped with the 24 tissue types. c Line plot showing the relative expression profiles for genes associated with each type of SEs. Each gene is normalized to its maximum value during differentiation and the average is shown. d, e Comparison of the gene expression fold changes (d) and specificity (e) for the three types of SEs. Fold change is defined as the gene expression in the last stage (day 15) divided by the expression level at the first stage (day 00). Specificity measures how the genes are specifically expressed on day 15 comparing to other time points (see the “Methods” section for details). *P < 0.05, **P < 0.01, ***P < 0.001. P-values are determined by using the Mann-Whitney U test. f Comparison of gene density near the three types of SEs. *P < 0.05, **P < 0.01, ***P < 0.001. P-values are determined by using the Mann-Whitney U test