Fig. 2
From: Genomic basis underlying the metabolome-mediated drought adaptation of maize
GWAS of the 1035 drought-responsive metabolites and the gene-metabolite networks. a Collection of the GWAS signals for the 1305 drought-responsive metabolites detected under WW (up panel) and DS (bottom panel) conditions. The dashed lines indicate the threshold of significance. The loci without significant SNPs were filtered out. All the 35 candidate genes with known drought tolerance roles were annotated based on the significant GWAS signals and indicated in the panels. b Density plot showing more significant SNPs associated with maize drought tolerance in the candidate genes as compared to the same number of randomly selected genes. The significance was calculated based on 1000 times of permutation test. c, d Gene-metabolite networks using 1035 drought-responsive metabolites and 2589 candidate genes under WW (c) and DS (d) conditions. Circles showing the chromosomal distribution of the genes associated with various numbers of metabolites under WW (c) and DS (d) conditions. The imbedded networks show the gene-metabolite associations or correlations under WW (c) and DS (d) conditions. Two hub genes ZmCS1 and ZmCS2 detected under both WW and DS conditions are indicated while two other hub genes Bx12 and ZmGLK44 detected only under DS conditions are indicated