Fig. 4

Impact of discrepancies between reference and target dataset. A Individual effect, region effect, and two dataset effects from the mouse brain datasets. The target is set as a mouse object from “Mouse brain FC”. The individual effect box contains 6 results from “Mouse brain FC”. Region effect uses subjects from “Mouse brain HC” to predict the target, which contains 6 results. “Mouse brain pFC” dataset effect contains 6 mouse subjects with saline treatment. “Mouse brain cortex” dataset effect contains 2 cortex samples. B Individual effect, batch effect, and clinical difference from the “Human PBMC lupus” dataset. The individual effect box contains 7 results from batch 1. The batch effect box contains individuals from batch 2 but under the same condition to predict the target which contains 8 results. The clinical difference contains individuals from batch 2 but under IFN-β treatment to predict the target which contains 8 results