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Fig. 6 | Genome Biology

Fig. 6

From: PUMAS: fine-tuning polygenic risk scores with GWAS summary statistics

Fig. 6

Identifying neuroimaging trait PRSs associated with AD. A QQ plot for the associations between 211 neuroimaging trait PRSs and AD. p-values were based on the meta-analysis of IGAP 2019 GWAS and the UK Biobank with a proxy AD phenotype. B Effect size estimates for top associations. Imaging trait PRSs that reached a p-value < 0.01 in the meta-analysis are shown in the plot. X-axis: effect sizes of imaging trait PRSs on the AD-proxy phenotype in the UK Biobank; Y-axis: effect sizes on AD in the IGAP 2019 GWAS. Imaging traits whose p-value achieved Bonferroni-corrected significance in the meta-analysis are highlighted in red. The dashed lines represent the standard error of effect size estimates

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