Fig. 6

Phenotypic heterogeneity of ASD probands with high PRS+ and PRS−. A Average IQ is computed for different groups defined by PRS. Each interval indicates standard error of the estimated mean. B PRS percentiles and IQ of probands above the 99% percentile of PRS−. PRS− was calculated using six negatively correlated regions between ASD and CP. The blue heatmap indicates the percentile of ASD PRS in each contributed region for each proband. The percentiles of PRS+ values are shown in the red boxes. IQ is shown as green bars. C PRS percentiles and IQ of probands above the 99% percentile of PRS+. PRS+ was calculated using 18 positively correlated regions between ASD and CP and the per-locus percentiles are shown in red. The percentiles of PRS+ are shown in blue and the green bars denote IQ