Fig. 4

Bidirectional local genetic covariance between ASD and CP. A Regions with significant local genetic covariance among ADHD, ASD, and CP (FDR < 0.1). This plot uses bars to break down the Venn diagram of overlapped regions in different categories. The five categories shown in the lower panel are correlated regions of ADHD and CP (positive and negative), ASD and CP (positive and negative), and ASD and ADHD (positive only). We use different colors (red, blue, and gray) to annotate region categories of positive, negative, and mixed covariance directions. B LocusZoom plots for ASD and CP GWAS associations at the KMT2E locus. ASD and CP are negatively correlated in the highlighted region. C LocusZoom plots for ASD and CP at the POU3F2 locus. ASD and CP are positively correlated in the highlighted region. POU3F2 is 700 kb downstream of the GWAS association peak