Fig. 3

Global and local genetic correlations among 30 complex traits. A Estimates of global genetic correlations (upper triangle) and estimated proportions of correlated regions among 435 trait pairs (lower triangle). Asterisks in the upper triangle highlight significant genetic correlations after Bonferroni correction for 435 pairs. Asterisks in the lower triangle indicate at least one significantly correlated region between the traits after Bonferroni correction for all 1,006,072 regions in 435 trait pairs. We grouped traits with hierarchical clustering applied to global genetic correlations. We summarized detailed information about each trait, including abbreviations, in Additional file 3: Supplementary Table 1. B Global genetic covariance estimates were highly concordant with the sums of local genetic covariance. Each point represents a trait pair. Color and shape of each data point denote the significance status in global and local correlation analyses. C Volcano plot comparing the global genetic correlation and proportion of correlated local regions. Each point represents a trait pair. Color of each data point represents the significance and direction of global correlation. Trait pairs discussed in the main text are labeled in the plot