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Fig. 6 | Genome Biology

Fig. 6

From: AMULET: a novel read count-based method for effective multiplet detection from single nucleus ATAC-seq data

Fig. 6

Majority of multiplets are homotypic and correspond to cell type proportions. a, b Heterotypic and homotypic multiplet cell distributions (left bars). Homotypic cell type annotations (right bars) for PBMC (a) and islet (b) samples. Majority of multiplets are annotated as homotypic. Homotypic cell type distributions show similar distribution to the overall proportions of each cell type in their respective samples. c Accessibility maps for cell origin annotations for multiplets identified in PBMC2. Homotypic multiplets observe strong signal for their respective marker genes. Heterotypic multiplets observe a combined signal at respective marker genes corresponding to the respective annotated cell types. d, e UMAP clustering for heterotypic and homotypic multiplet annotations in PBMC1 (d) and isletĀ 1 (e). Heterotypic multiplets are found between major cell type clusters. Homotypic multiplets are observed on the periphery of major cell type clusters. f, g Cell and multiplet proportions for PBMC2 (f) and isletĀ 1 (g). Multiplet cell type proportions are highly correlated with overall cell proportions

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