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Fig. 2 | Genome Biology

Fig. 2

From: AMULET: a novel read count-based method for effective multiplet detection from single nucleus ATAC-seq data

Fig. 2

AMULET identifies heterotypic and homotypic snATAC-seq multiplets in primary human tissues. a Summary of snATAC-seq samples generated and used in this study from human PBMCs and islets. b Valid read pair distributions for PBMC and islet snATAC-seq samples. c PBMC clusters were annotated based on their correlations with sorted bulk ATAC-seq data. d All multiplets (heterotypic and homotypic) detected by AMULET in PBMC1. Selected multiplets refer to multiplets for which aggregated profiles are shown in panel f of this figure. e The number of cells and percentage of multiplets detected by AMULET in PBMC and islet samples. f Chromatin accessibility profiles of CD4+ T, myeloid, and selected multiplets around for T cell marker gene (CD3G) and myeloid cell marker gene (LYZ). CD4+ T and myeloid cells show strong accessibility signals for their relevant marker genes while selected multiplets have accessible chromatin for both marker genes

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