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Fig. 5 | Genome Biology

Fig. 5

From: NucHMM: a method for quantitative modeling of nucleosome organization identifying functional nucleosome states distinctly associated with splicing potentiality

Fig. 5

The functional nucleosome states associated with the splicing potentiality of SEs. A H3K79me2-related NucSs signals center on exons. NucS10 showed the highest enrichment in exons. B A bar plot showed different SE affinity of each H3K79me2-related NucSs in each cell type. Briefly, we counted the raw number of SE events for each H3K79me2-related NucSs in each cell type and then assumed SE event was randomly associated with NucSs to get the predicted SE events. Finally, we used the ratio of raw vs predicted number as the SE event affinity for each H3K79me2-related NucS. NucS10 showed a higher SE affinity among all three cell types. C Semi-quantifying the SE potentiality of each H3K79me2-related NucSs. The NucS10 consistently had the highest SE potentiality score. We assessed SE potentiality from three aspects: the Frechet distance between the nucleosome distribution of SE and no-SE; the nucleosome positioning difference between nucleosomes in SE and no-SE region; the normalized SE events of each NucS

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