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Fig. 4 | Genome Biology

Fig. 4

From: BRIE2: computational identification of splicing phenotypes from single-cell transcriptomic experiments

Fig. 4

Differential momentum genes for RNA velocity. a, b Cell differentiation in neurogenesis inferred from RNA velocity by scVelo with different gene sets: a scVelo detected gene set requiring positive correlation between unspliced and spliced RNAs, and b BRIE2 detected gene set that have differential spliced ratio in one cell type vs all others, which are termed as differential momentum genes. c, d State transitions of excitatory neurons inferred from RNA velocity with different methods: c Dynamo using metabolic labelling information measured by scNT-seq. d scVelo using total RNAs on 201 differential momentum genes detected by BRIE2. The colour denotes the time since stimulations: 0 (blue), 15 (orange), 30 (green), 60 (red), and 120 (purple) minutes

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