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Fig. 3 | Genome Biology

Fig. 3

From: BRIE2: computational identification of splicing phenotypes from single-cell transcriptomic experiments

Fig. 3

Differential splicing events on multiple sclerosis. a UMAP visualisation of gene-level expression, annotated with cell types and EAE state. b UMAP coloured by the first principal component based on PSI matrix, which suggests that PSI PC has a global impact on cell types. c Volcano plot between ELBO_gain and effect size on logit(PSI) for detecting differential splicing between EAE and control cells by BRIE2. d Violin plot on example gene Mbp (the exon3) for estimated PSI between EAE and control in each cell type. Note, the PSI values in b and d are quantified by only using a unity cell feature for aggregation, but not the EAE state label. EAE, Experimental Autoimmune Encephalomyelitis

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