Fig. 2

Evaluation of BRIE2 on detection of differential alternative splicing with simulated data. a Mean PSI of cells in condition 1 (x-axis) and condition 2 (y-axis), where 400 out of for 2248 events are differential alternative splicing (DAS, coloured in orange). The effect size level L2 means effect size at logit scale is 2. b Precision-recall curve for detecting the DAS from simulated single-cell RNA-seq reads by BRIE2, rMATS and MAJIQ. The effect size is L2, as shown in a. Black circles on the curve denote cutoff of ELBO_gain>3 for BRIE2 or |delta_PSI|>0.2 for rMATS and MAJIQ. Similar to a and b, more simulations and results are shown with effect size level L3 (c, d) and L5 (e, f), respectively