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Fig. 1 | Genome Biology

Fig. 1

From: Quantifying the phase separation property of chromatin-associated proteins under physiological conditions using an anti-1,6-hexanediol index

Fig. 1

Hi-MS effectively enrich chromatin-associated proteins. A Schematic of Hi-MS. B The examples of GGCC distribution in the gene promoter region. Top, RUNX1; bottom, POLE4. These two regions were selected as represents of super enhancer and typical enhancer [23]. C The distribution of human genome sequence GATC and GGCC proximate to H3K27ac and EZH2 binding peaks. D Chromatin-associated proteins are effectively enriched by Hi-MS compared with undigested control. E MS/control fold enrichment of NUPs agreed with their spatial location. NPC model was adapted from Ref [24]

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