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Fig. 7 | Genome Biology

Fig. 7

From: Time-dependent effect of 1,6-hexanediol on biomolecular condensates and 3D chromatin organization

Fig. 7

Interactions between condensate-enriched regions were long-range and weakened upon 1,6-HD treatment. A Distance of “condensate-enriched interactions,” “condensate-absent interactions,” and “random interactions.” Condensate-enriched interactions: both ends overlapping with 40 kb bins with top 10% ChIP-seq signals of key components of specific condensates. Condensate-absent interactions: both ends overlapping 40 kb bins with bottom 10% signals. Random interactions: both ends overlapping randomly selected 10% bins. B Aggregate peak analysis (APA) of long-range condensate-enriched interactions (≥ 10 Mb) at 40 kb resolution. C Average interactions surrounding the center (< 120 kb) of long-range condensate-enriched interactions (≥ 10 Mb). All p values were determined by the Wilcoxon rank-sum test. D Aggregate peak analysis (APA) of structural factor-mediated interactions at 10 kb resolution. E Average interactions surrounding the center (< 30 kb) of structural factor-mediated interactions. Pairwise Wilcoxon rank-sum test was performed but no significant changes were detected. F Schematic indicating that interactions between condensate-enriched regions are long-range and weakened upon 1,6-HD treatment

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