Fig. 9
From: Straglr: discovering and genotyping tandem repeat expansions using whole genome long-read sequences
Straglr workflow. Straglr has two stages: Scan and Genotype. Inputting a bam file, the Scan stage identifies insertions, filters them for tandem repeats, and merges reads to annotate events at target loci. Inputting bam and bed files, the Genotype stage uses a Gaussian mixture model to cluster reads into alleles to report copy numbers of repeat motifs and the nucleotide lengths of tandem repeats