Fig. 3From: Systematic assessment of gene co-regulation within chromatin domains determines differentially active domains across human cancersImmune chromatin domains. a Gene ontology (GO) categories significantly enriched for genes in domains that were found differentially active in multiple datasets (n > 7). b Distribution of the average correlation of gene expression with tumor purity for all domains (gray) and differentially active domains only (red). The dashed line indicates the 0.05-quantile of the distribution for all domains, used as a threshold for the detection of immune domains. c Percentage of immune domains among all domains (Y-axis) and among differentially active domains (X-axis). The dashed red line indicates the y=x line. Each dot is a dataset, the color indicates the comparison category. d FCC AUC ratios obtained after removing immune domains (barplot) versus FCC AUC ratio values obtained without filtering (dots). Color indicates the comparison category. e Comparison of the number of differentially active domains in the observed and random domain partitions after removing immune domains.Back to article page