Fig. 5

The impact of pericentromeric heterochromatin on genome compartmentalization. a–c Three chromosomes (Chr4, Chr19, Chr2) representing the metacentric, submetacentric, and telocentric chromosomes, respectively. The legends for the Hi-C contact map, repeat content, distribution of Cen-524, gene density, H3K9me3 modification, and A/B compartments are similar to these described in Fig. 3g, h. The Rec. panel shows the recombination rate (c/bp) estimated with variable window sizes based on the number of available variants. d Positive correlation of the chromosome size and PCH size. The colors are the measures of the proportions of PCH over the chromosomes. e Interaction is more frequent between PCH chromatin over various genomic distance than between non-PCH. f Genes are expressed at a higher level in PCH than in non-PCH