From: MAAPER: model-based analysis of alternative polyadenylation using 3′ end-linked reads
MAAPER | scAPA | Sierra | |
---|---|---|---|
Input data type | Bulk RNA-seq or scRNA-seq | scRNA-seq | scRNA-seq |
Applicable to multiple samples | Yes | Yes | Yes |
PAS resolution | Individual PAS | Range based on read peak | Range based on read peak |
PAS identification method | Modeling based on known PASs | De novo | Do novo |
Basis for PAS quantification | Cell cluster | Single cell | Single cell |
Basis for APA analysis | Cell cluster | Cell cluster | Cell cluster |
Individual-based paired test | Yes | No | No |