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Fig. 2 | Genome Biology

Fig. 2

From: Genomic diversity and ecology of human-associated Akkermansia species in the gut microbiome revealed by extensive metagenomic assembly

Fig. 2

Prevalence and insights into the ecological and functional characteristics of Akkermansia candidate species. A Akkermansia candidate species have variable prevalence across hosts and wild versus captive mice and non-human primates. We computed prevalences using species-specific marker genes (see the “Methods” section) applied on a total of 13,237 metagenomic samples. B, C Akkermansia candidate species are strongly mutually exclusive (analysis based on 4171 Akkermansia-positive human metagenomes). D A. muciniphila but not the other Akkermansia candidate species is associated with decreased host body mass index (BMI) according to a meta-analysis random effect model of partial correlations adjusted for age and sex (see the “Methods” section) comprising 3311 human metagenomic samples from 22 datasets (Additional file 1: Table S2). E Corrin ring biosynthesis operon genes are consistently present only in candidate species SGB9227 and SGB9228 (see the “Methods” section). F Growth analysis of the A. muciniphila and A. glycaniphila type strains shows propionate production by PytT but not MucT in the absence of vitamin B12. This is indicative of endogenous production of vitamin B12 (acting as a cofactor for the methyl-malonyl CoA synthase reaction) by PytT but not MucT. G Core gene genetic distances are correlated with corrin ring biosynthesis gene genetic distances. Pairwise distances were computed only for strains in which all genes were found together on the same contig

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