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Fig. 1 | Genome Biology

Fig. 1

From: STRONG: metagenomics strain resolution on assembly graphs

Fig. 1

STRONG pipeline. This figure illustrates the principal steps in the STRONG pipeline (see “Methods - STRONG pipeline” section). Step 1) Co-assembly with metaSPAdes and storage of a high-resolution graph (HRG). Step 2) Contig binning with CONCOCT or Metabat2 and annotation of single-copy core genes (SCGs). Step 3) Mapping of SCGs onto the HRG and extraction of individual SCG assembly graphs together with per-sample unitig coverages. Step 4) Joint solution of SCG assembly graphs from each MAG with BayesPaths to determine strain number, haplotypes and per-sample coverages

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