Fig. 6
From: Elevated retrotransposon activity and genomic instability in primed pluripotent stem cells
Primed mEpiSCs harbor more CNVs than do naïve mESCs. A Circos plot showing genetic alterations in primed cells from CBA × C57 genetic background. The red circle represents CNVs. n = 4 different cell line clones. B Genome distribution of CNVs in primed cells. C Number of gained and lost CNVs in primed cells. D Percentage of CNVs with different TE numbers. Four classes of CNVs were classified according to the number of overlapped TEs. E Number of TEs in the top five families contained within gained or lost CNVs sequence. F Genome browser view of the distribution of CNVs identified in chromosome 5 in primed cells. Blue markers represent gained CNVs. G Genome browser view by IGV of the distribution of gained CNVs identified in chromosome 5 mapping with TEs in primed cells. H Genome browser view of the distribution of CNVs identified in chromosome 2 in primed cells. Blue markers represent gained CNVs. I Genome browser view by IGV of the distribution of gained CNVs identified in chromosome 2 mapping with TEs in primed cells. All n = 4