Fig. 4

Locus zoom plots for the four associations in CFW outbred mice that were subsequently tested in an experiment with Epha4 and Dlgap1 knockout models. a Significant IGE locus on chromosome 1 for immobility during the first 2 min of the forced swim test (FST), a measure of stress-coping strategy. Epha4 was identified as the only putative causal gene at this locus (see the “Methods” section). b Same locus and phenotype but DGE, rather than IGE, are shown. The plot shows little evidence of DGE on FST immobility at the Epha4 locus. c Suggestive IGE association at the Epha4 locus with rate of healing from an ear punch, a phenotype of particular interest (-logP = 4.1, FDR > 10%). d Second significant (FDR < 10%) IGE locus for immobility in the FST (this time measured during the last 4 min of the test). Dlgap1 is one of eight putative causal genes at this locus. It was singled out because of its functional similarity and co-expression with Epha4 (see main text)