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Fig. 5 | Genome Biology

Fig. 5

From: Integration of metabolomics, genomics, and immune phenotypes reveals the causal roles of metabolites in disease

Fig. 5

Arachidonic acid has a causal effect on Crohn’s disease through an mQTL locus. a Box plot of arachidonic acid level with genotype at rs174584. b Locus zoom plots of arachidonic acid QTL profile and Crohn’s disease GWAS profiles showing colocalization through the rs174584 locus. c Mendelian randomization results. d Box plot of blood FADS2 expression level with genotype at rs174584. e Box plot showing arachidonic acid level changes with FADS2 levels in the blood. f Box plot of FADS2 expression level in Crohn’s disease (CD) biopsies versus control g A graphic summary of the regulation network of mQTL (rs174584-FADS2)

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Genome Biology

ISSN: 1474-760X

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