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Table 2 Summary of the six key aggregation-normalization strategies used in this study. In particular, for each approach, we specify the aggregation method used, the type of normalization adopted, and the level of aggregation selected

From: Optimizing expression quantitative trait locus mapping workflows for single-cell studies

Aggregation method Normalization Aggregation level
dr-mean Mean Single-cell level (scran) Donor and run
dr-median Median Single-cell level (scran) Donor and run
dr-sum Sum Pseudo-bulk level (TMM) Donor and run
d-mean Mean Single-cell level (scran) Donor
d-median Median Single-cell level (scran) Donor
d-sum Sum Pseudo-bulk level (TMM) Donor