Table 2 Summary of the six key aggregation-normalization strategies used in this study. In particular, for each approach, we specify the aggregation method used, the type of normalization adopted, and the level of aggregation selected
From: Optimizing expression quantitative trait locus mapping workflows for single-cell studies
| Â | Definition | ||
|---|---|---|---|
Aggregation method | Normalization | Aggregation level | |
dr-mean | Mean | Single-cell level (scran) | Donor and run |
dr-median | Median | Single-cell level (scran) | Donor and run |
dr-sum | Sum | Pseudo-bulk level (TMM) | Donor and run |
d-mean | Mean | Single-cell level (scran) | Donor |
d-median | Median | Single-cell level (scran) | Donor |
d-sum | Sum | Pseudo-bulk level (TMM) | Donor |