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Fig. 5 | Genome Biology

Fig. 5

From: SMOOTH-seq: single-cell genome sequencing of human cells on a third-generation sequencing platform

Fig. 5

SV detection in colorectal carcinoma (CRC) cells using SMOOTH-seq. a A comprehensive overview of SVs detected by SMOOTH-seq in single CRC cells. b The number of insertions, deletions, translocations, and duplications events in a patient’s colorectal carcinoma sample. c, d, e Histograms of length distributions for insertion, deletion, and duplication events detected by SMOOTH-seq in CRC cells. f PCR validation of insertions events in cancer tissue but not existing in normal tissue, GM 12878, or peripheral blood mononuclear cell. N, cancer adjacent normal tissue. C, cancer tissue. GM, GM 12878. PB, peripheral blood mononuclear cell. g An example of insertions in cancer tissue whose insertion site located at the intron of BRAF gene. h The location distributions of ecDNA in cancer tissue on chromosomes

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