Fig. 4
Candidate adaptive genes. A All linkage disequilibrium (LD)-linked genes across tissues. Known adaptive genes were marked in red color. B The rank of effect size and the p-value (-log10) for eQTLs across tissues. C All three-dimensional (3D) interactions and the corresponding genes affected by 69 population-stratified structural variations (SVs) (fixation index [FST] > 0.1 between Tibetans and Hans). The outermost green layer represents the transcription regions of affected genes. Deletions (DEL) will remove overlapped interactions (blue), and insertions (INS) could create a new anchor (red) or duplicate nearby anchors and then construct new interactions with the closest anchors (green). D Gene-Ontology (GO) and E hypoxia-related pathway enrichment analysis for 80 candidate genes