Fig. 4

Co-expression networks for LUAD subgroups and group-specific core regulators. a Co-expression network (bipartite network) constructed in GI (orange) and GII (purple) based on gene expression correlations between differentially expressed transcription factors or epigenetic regulators and their target genes. b Co-expression network of differentially expressed regulators. Core regulators in GI (6 core regulators, left panel) and GII (18 core regulators, right panel), core regulators formed a highly connected clique in the regulator co-expression networks. c Core regulators(red) and other regulators(grey) with their degrees calculated from the bipartite networks in a, p-value determined by rank-sum test. d Upstream differential epigenetic elements participate in regulation in group-specific core regulator, including differential distal enhancers, differential proximal peaks, and differential super-enhancers