Fig. 5

Chromatin conformation dynamics during a circadian cycle. Circadian TADs containing one or more circadian genes remain stable but overlap with regions that switch chromatin compartments in correlation with transcriptional activation and gain of open histone modifications marks during the 24 h (left). Inside cTADs, circadian genes and regulatory elements with similar acrophases contact each other in the nuclear space with interactions increasing at the time of peak transcription (middle). Core clock genes display highly dynamic contacts during the 24 h. In contrast, circadian output genes have more saturated contact profiles that remain stable during the day (right)