Fig. 5

Differential expression of micro-RNAs between mice treated by sham surgery (Sham) and mice treated by transverse aortic constriction (TAC). The tree organizing the miRNAs by their origin and biogenesis is shown in the innermost circle with four levels of hierarchy: level 1 includes genomic clusters (i.e., groups of miRNAs which are located in “relatively close” regions on the genome (<10 kb)); level 2 has the primary transcript or host gene; level 3 has single-strand miRNA (e.g., mmu-miR-22-3p); and level 4 has mature sequences. Nodes identified by treeclimbR are in red points. Up- and downregulated DA branches are shown in blue and orange, respectively. Log-expressions of sequences in identified branches are scaled and shown in the heatmap surrounding the tree. Identified branches that have at least 10 leaves are annotated, and those with more than one miRNA are labeled as mixed. The genomic ranges of identified clusters are indicated in points with different colors