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Fig. 1 | Genome Biology

Fig. 1

From: On the optimistic performance evaluation of newly introduced bioinformatic methods

Fig. 1

We examine the point in time where a method “A” exists in the literature, and a new method “B” is introduced. In the paper presenting method B, the authors compare it to method A: a “non-neutral comparison” (dark red color, see also Fig. 2), as method B’s authors may have some bias in presenting the results. Some time later, a paper introducing another method, “C”, is published. The authors compare C to existing methods A and B, which implies also a comparison of B to A, although this comparison is not the study’s focus. This latter study is assumed to be neutral (dark blue color, see also Fig. 2) with respect to A and B and is termed a “neutral benchmark study”

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