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Fig. 5 | Genome Biology

Fig. 5

From: Tejaas: reverse regression increases power for detecting trans-eQTLs

Fig. 5

Trans-eQTLs are enriched among GWAS risk SNPs for complex diseases. aTrans-eQTLs are enriched with SNPs from the GWAS Catalog. Significance is denoted by * for p ≤0.05, ** for p ≤0.01, and *** for p ≤0.001. b Enrichment of cis-eQTLs (left panel) identified by GTEx consortium and enrichment of trans-eQTLs (right panel) identified by Tejaas for 11 disease categories compiled from 86 GWAS of complex diseases [30] (tissue colors as in Fig. 3a). The enrichment generally increases with decreasing p value cutoff (x-axis) for the GWAS-associated SNPs. Only those tissues with significant enrichment (p ≤0.05) at a cutoff of p = 1 ×10-6 are shown in the plot. While cis-eQTLs are enriched for the majority of tissues, enrichment of trans-eQTLs in any disease category is tissue-specific, and the top two tissues with maximum enrichments are noted in the legends

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