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Fig. 6 | Genome Biology

Fig. 6

From: Ten-eleven translocation protein 1 modulates medulloblastoma progression

Fig. 6

Pdgfrs are potential downstream targets of Tet1. a Co-immunoprecipitation of Nanog with Tet1 protein in SmoA1-MB. b Stepwise identification of DhMRs bound by Tet1 and Nanog as well as located at promoter-TSS regions. c Scatterplot illustrating the expression of transcripts with either gain-of-5hmC or loss-of-5hmC at their promoter-TSS regions. Red dots indicate transcripts significantly either upregulated or downregulated in SmoA1-MB. d Summary table of genes with differential 5hmC levels at their promoter-TSS regions and gene expression. e Peaks of Tet1 and Nanog from ChIP-Seq studies [57,58,59] and 5hmC peaks from MBs and NCs in the Pdgfra and Pdgfrb loci. The loci highlighted by dotted rectangles were further validated by TET1 ChIP-qPCR. f Both Pdgfra and Pdgfrb expressions are downregulated upon TET1 inhibitor treatment (**p < 0.01, ***p < 0.001, and ***p < 0.0001)

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