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Table 3 Overview of published genome-wide DNA methylation quantitative trait loci studies in blood-independent sample types

From: Genetic impacts on DNA methylation: research findings and future perspectives

Sample type Association Methylation Sample sizesb Significant Significant Ref.
  analysesa assays   cis-CpGsb trans-CpGsb  
Brain 18 Illumina 450K, 18–468 0.1–13.6% 0.1–5.1% [47, 48, 57, 70, 71, 79, 80, 86, 174]
   Illumina 27K     
Buccal 2 Illumina EPIC 86–197 4.3–7.4%   [39, 73]
Cancer 23 Illumina 450K 103–664 1.7–6.4% 0.1–24.8% [72]
Connective tissue (adipose, fibroblasts) 4 Illumina 450K, 107–603 3.2–28.5% 0.1% [31, 59, 65, 76]
   MCC-seq     
Epithelial 1 Illumina 450K 111 4.4%   [175]
Lung 2 Illumina 450K 126–210 10–10.1% 0.2% [56, 82]
Placenta 2 Illumina 450K 37–303 0.2–0.9%   [70, 176]
Skeletal muscle 1 Illumina EPIC 282 20.6%   [83]
  1. aWe account for the different association analyses, even if they are published in the same paper
  2. bIf more than one analyses is available, the range is presented