Genetic impacts on DNA methylation: research findings and future perspectives

Table 3 Overview of published genome-wide DNA methylation quantitative trait loci studies in blood-independent sample types

Sample type	Association	Methylation	Sample sizes^b	Significant	Significant	Ref.
	analyses^a	assays		cis-CpGs^b	trans-CpGs^b
Brain	18	Illumina 450K,	18–468	0.1–13.6%	0.1–5.1%	[47, 48, 57, 70, 71, 79, 80, 86, 174]
		Illumina 27K
Buccal	2	Illumina EPIC	86–197	4.3–7.4%		[39, 73]
Cancer	23	Illumina 450K	103–664	1.7–6.4%	0.1–24.8%	[72]
Connective tissue (adipose, fibroblasts)	4	Illumina 450K,	107–603	3.2–28.5%	0.1%	[31, 59, 65, 76]
		MCC-seq
Epithelial	1	Illumina 450K	111	4.4%		[175]
Lung	2	Illumina 450K	126–210	10–10.1%	0.2%	[56, 82]
Placenta	2	Illumina 450K	37–303	0.2–0.9%		[70, 176]
Skeletal muscle	1	Illumina EPIC	282	20.6%		[83]

^aWe account for the different association analyses, even if they are published in the same paper
^bIf more than one analyses is available, the range is presented

ISSN: 1474-760X