Fig. 4
From: Promoter G-quadruplex folding precedes transcription and is controlled by chromatin
Model showing an interaction between promoter G4s, Pol II and chromatin status. a Promoter G4 folding is seen in accessible promoter regions. Pol II is recruited to the G4 to promote transcription. b Transcriptional inhibition does not cause loss of promoter G4 folding. c Chromatin compaction causes G4 unfolding and loss of Pol II binding. d Ligand-mediated G4 stabilisation (red star) can preserve promoter G4 folding under conditions of chromatin compaction, which in turn causes retention of Pol II