Fig. 4
From: scMET: Bayesian modeling of DNA methylation heterogeneity at single-cell resolution
scMET applied to the multi-omics scNMT-seq gastrulation dataset reveals a complex linkage between promoter DNAm and RNA expression during embryonic development. a Scatter plot displays posterior median estimates for residual DNAm overdispersion parameters εj in gene promoters (x-axis) versus RNA residual overdispersion of the corresponding genes (y-axis). Among the genes with high levels of RNA heterogeneity, green and pink points correspond to promoters showing high and low levels of DNAm variability, respectively. b Representative examples of DNAm and RNA expression patterns across developmental stages for genes with high transcriptional heterogeneity and low (left, pink) or high (right, green) DNAm heterogeneity. The y-axis shows BASiCS log-normalized gene expression (in a log(x+1) scale) (top) and promoter DNAm rate (bottom). Cells are stratified by embryonic stage (x-axis)