Skip to main content
Fig. 3 | Genome Biology

Fig. 3

From: Computational methods for chromosome-scale haplotype reconstruction

Fig. 3

Haplotype-aware de novo assembly. Collapsed assembly approaches identify sequence variants on a consensus assembly and subsequently phase these variants into haplotypes using chromosome-scale data (Hi-C). Semi-collapsed approaches follow a similar approach, but after phasing, variants in the initial assembly graph are updated and final contigs are produced based on this updated graph. Uncollapsed approaches directly determine haplotype-specific overlaps in local sequencing reads by retaining SNPs and repeat variation in all possible overlaps and construct haplotypes based on the selected overlaps

Back to article page