Table 1 A comparison of the strengths and limitations of different methods for assaying crossovers. The assumptions used to build the table are the following: A male mouse would be used to obtain sperm. The mouse genome is approximately 2.5 Gbp, and generation times require 12 weeks. In bead-based single-cell experiments, 1000 gametes are captured and sequenced. 1× genome coverage is used in all sequence-based experiments. Representative costs have been used from experiments in our laboratories, or appropriate quotes, and are intended as a guide only. Costs are only for reagents and sequencing. Costs are not included for wet-lab and bioinformatics researchers, animal housing costs, and equipment.

From: Personalized genome structure via single gamete sequencing