Skip to main content
Fig. 5 | Genome Biology

Fig. 5

From: Subtype-associated epigenomic landscape and 3D genome structure in bladder cancer

Fig. 5

NPAS2 is a novel bladder cancer regulator. a p-values of NPAS2 motif in luminal-associated (RT4, SW780), basal-associated (SCABER, HT1376), and shared open chromatin regions. b NPAS2 ChIP-seq signal near luminal marker genes FOXA1, GATA3, and PPARG in HEPG2 cell line. c NPAS2 Kaplan-Meier curve is shown here for 2000 days with log-rank statistics and hazards ratio. d Transwell migration assay representative crystal violet staining (left) and quantification of differences in transwell migration (right) are shown following overexpression of NPAS2 in SCABER. e RT-qPCR results for basal marker genes KRT5, KRT6A, STAT3, and TFAP2C are shown here for wild-type and NPAS2 overexpressed SCABER basal cell line. f NPAS2, FOXA1/GATA3, and PPARG RT-qPCR are shown here for wildtype and FOXA1/GATA3 overexpressed SCABER basal cell line

Back to article page