Fig. 2

Distinct sets of transcription factor motifs are enriched in luminal and basal BLCA-associated cis DNA regulatory regions. a A comprehensive and a distinct set of distal ATAC-Seq signals at three clusters (luminal specific, basal specific, and shared) and corresponding H3K27ac signals. b TF motif analysis results is shown here as a ranked plot (left) and motifs (right), where for luminal-specific (top) and basal-squamous-specific open chromatin enhancers (bottom). c FOXA1 and GATA3 bound open chromatins located at distal enhancers of RT4/luminal cell line is depicted here in three groups: FOXA1 only, GATA3 only, and FOXA1 and GATA3 binding sites. d Gene ontology analysis of pathways for each group of binding sites (FOXA1 only, FOXA1 and GATA3, and GATA3 only). e Observed occurrence of TF motifs (AP-1, FOX Forkhead, and GATA) is shown here at distal enhancers and promoters of three groups. f Genome-wide open chromatins of BLCA cell lines show similarity with TCGA bladder tumors [30]