Table 1 Proteome of enhancers

TFs

Sequence-specific TFs that bind enhancers directly and other TFs recruited via protein-protein interactions—classified into distinct structural and functional groups

[68, 82, 83, 89, 90]

General Transcription Factors (GTFs)

[91,92,93]

Architectural proteins

Chromatin enriched with histone H3K4me1, H3K27ac; H3.3, H2Az

[94]

Cohesin, Condensin, CTCF

[82, 95,96,97]

Coregulators

Mediator complex

[95, 98]

Chromatin remodeling complexes and chromatin-modifying enzymes (“writers” and “erasers” of post-translational modifications)

[99]

Integrator complex

[100]

Steroid receptor coactivators and other coregulators of TFs

[81, 83, 84]

Effector proteins

Proteins that “read” histone post-translational modifications

[94, 101]

Catalytic enzymes

RNAPII and associated enzymes

[93]

Other enzymes (RNA exosome complex; PARP-1; Topoisomerase-1; TET2, etc.)

[102,103,104,105]