Fig. 4

Illustration of considerations for determining positives and negatives within the reference material. Each WES kit coverage is shown relative to their intersection with coding regions (Interval4), the high confidence region, and the low complexity region. Also shown are known positive variant positions in Sample A (mostly Class 1 variants SNVs) including one identified by a violet box that is outside the Interval4 and CTR regions (Class 2 variant). Other positions shown include known negative positions