Fig. 2

Reproducibility and sensitivity across VAF ranges for SNVs in the consensus targeted regions. a Table listed the number of known variants in each VAF range (left number), sensitivity (right number) for all 8 panels across all samples tested. For the panels with a built-in VAF threshold, “N/A” is listed if the VAF low bound is much lower than the panel provider’s chosen VAF threshold. The VAF threshold is 2.6% for ILM, 2.0% for IDT, 2.5% for ROC, and 2.5% for TFS, respectively. b Average false positive SNV calls per million across various VAF cutoffs. Jittering was applied to avoid overlapping. c Cross-lab and intra-lab reproducibility (in Phred scale) for variant calls with VAF between 2.5 and 20%