Skip to main content
Fig. 6 | Genome Biology

Fig. 6

From: Histone lactylation drives oncogenesis by facilitating m6A reader protein YTHDF2 expression in ocular melanoma

Fig. 6

Anticancer effects of glycolysis inhibitors could be partially prevented by YTHDF2. a Western blot showed that YTHDF2 was overexpressed in ocular melanoma cells after transfected with plasmid carrying YTHDF2 gene. b, c Proliferation of OCM1 (b) and CRMM1 (c) cells with or without YTHDF2 overexpression treated with oxamate was analyzed by CCK8 assay. **p < 0.01. d Tumor growth of OCM1 and CRMM1 cells with or without YTHDF2 overexpression treated with oxamate was evaluated by colony formation assay. e Statistical analysis of the colony formation assay performed using OCM1 and CRMM1 cells with or without YTHDF2 overexpression treated with oxamate. All of the experiments were performed in triplicate, and relative colony numbers are shown as means ± SD. *p < 0.05, **p < 0.01. f The migratory ability of OCM1 and CRMM1 cells with or without YTHDF2 overexpression treated with oxamate was evaluated by transwell assay. g Statistical analysis of cells in the transwell assay performed using OCM1 and CRMM1 cells with or without YTHDF2 overexpression treated with oxamate. All of the experiments were performed in triplicate, and relative cell numbers are shown as means ± SD. *p < 0.05, **p < 0.01

Back to article page